Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 1
1999 4
2000 1
2002 2
2003 3
2004 2
2005 1
2006 2
2010 1
2011 3
2012 3
2013 1
2014 5
2017 1
2019 1
2020 1
2024 1

Text availability

Article attribute

Article type

Publication date

Search Results

30 results

Results by year

Filters applied: . Clear all
Page 1
The Hand2 gene dosage effect in developmental defects and human congenital disorders.
Tamura M, Amano T, Shiroishi T. Tamura M, et al. Curr Top Dev Biol. 2014;110:129-52. doi: 10.1016/B978-0-12-405943-6.00003-8. Curr Top Dev Biol. 2014. PMID: 25248475 Review.
Recently, comparative analyses of a human chromosomal disorder, partial trisomy distal 4q, and its mouse model, which is a spontaneously occurring mutant, clearly demonstrated that over dosage of Hand2 results in developmental defects of limbs, craniofacial, and lum …
Recently, comparative analyses of a human chromosomal disorder, partial trisomy distal 4q, and its mouse model, which is a spontaneously occ …
Intercellular Genetic Interaction Between Irf6 and Twist1 during Craniofacial Development.
Fakhouri WD, Metwalli K, Naji A, Bakhiet S, Quispe-Salcedo A, Nitschke L, Kousa YA, Schutte BC. Fakhouri WD, et al. Sci Rep. 2017 Aug 2;7(1):7129. doi: 10.1038/s41598-017-06310-z. Sci Rep. 2017. PMID: 28769044 Free PMC article.
Interferon Regulatory Factor 6 (IRF6) and TWIST1 are transcription factors necessary for craniofacial development. Human genetic studies showed that mutations in IRF6 lead to cleft lip and palate and mandibular abnormalities. ...Considering that variants in IRF6 and …
Interferon Regulatory Factor 6 (IRF6) and TWIST1 are transcription factors necessary for craniofacial development. Human genetic stud …
Requirement of Hyaluronan Synthase-2 in Craniofacial and Palate Development.
Lan Y, Qin C, Jiang R. Lan Y, et al. J Dent Res. 2019 Nov;98(12):1367-1375. doi: 10.1177/0022034519872478. Epub 2019 Sep 11. J Dent Res. 2019. PMID: 31509714 Free PMC article.
In this study, we show that Has2, 1 of 3 hyaluronan synthases in mammals, plays a major role in hyaluronan synthesis in the neural crest-derived craniofacial mesenchyme during palatogenesis in mice. We analyzed developmental defects caused by tissue-specific inactivation o …
In this study, we show that Has2, 1 of 3 hyaluronan synthases in mammals, plays a major role in hyaluronan synthesis in the neural crest-der …
Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities.
Firulli BA, Krawchuk D, Centonze VE, Vargesson N, Virshup DM, Conway SJ, Cserjesi P, Laufer E, Firulli AB. Firulli BA, et al. Nat Genet. 2005 Apr;37(4):373-81. doi: 10.1038/ng1525. Epub 2005 Feb 27. Nat Genet. 2005. PMID: 15735646 Free PMC article.
We show that ectopic expression of the related basic helix-loop-helix factor Hand2 phenocopies Twist1 loss of function in the limb and that the two factors have a gene dosage-dependent antagonistic interaction. Dimerization partner choice by Twist1 and Hand2 can be …
We show that ectopic expression of the related basic helix-loop-helix factor Hand2 phenocopies Twist1 loss of function in the limb an …
Prevention of retinoic acid-induced early craniofacial abnormalities by vitamin B12 in mice.
Zhang Z, Wang J, Dai X, Ding Y, Li Y. Zhang Z, et al. Cleft Palate Craniofac J. 2011 Jul;48(4):355-62. doi: 10.1597/09-156. Epub 2010 Jul 1. Cleft Palate Craniofac J. 2011. PMID: 20815727
CONCLUSIONS: These results suggest that vitamin B12 may prevent RA-induced craniofacial abnormalities via prevention of an RA-induced decrease of ET-1 and dHAND protein levels in the branchial region during the organogenic period. This study may shed new light on pr …
CONCLUSIONS: These results suggest that vitamin B12 may prevent RA-induced craniofacial abnormalities via prevention of an RA- …
Prevention of retinoic acid-induced early craniofacial abnormalities by folinic acid and expression of endothelin-1/dHAND in the branchial arches in mouse.
Zhang Z, Xu Y, Li L, Han J, Zheng L, Liu P, Li Y. Zhang Z, et al. Br J Nutr. 2006 Sep;96(3):418-25. Br J Nutr. 2006. PMID: 16925845
Prevention of retinoic acid-induced craniofacial abnormalities by folinic acid, and endothelin-1 (ET-1)/dHAND protein and mRNA expression were investigated in mouse embryos using the whole embryo culture, streptavidin-biotin peroxidase complex method, and whole-moun …
Prevention of retinoic acid-induced craniofacial abnormalities by folinic acid, and endothelin-1 (ET-1)/dHAND protein and mRNA …
Genetic and comparative mapping of genes dysregulated in mouse hearts lacking the Hand2 transcription factor gene.
Villanueva MP, Aiyer AR, Muller S, Pletcher MT, Liu X, Emanuel B, Srivastava D, Reeves RH. Villanueva MP, et al. Genomics. 2002 Dec;80(6):593-600. doi: 10.1006/geno.2002.7009. Genomics. 2002. PMID: 12504851
We used differential display analysis to identify 33 putative HAND2-regulated ESTs that are differentially expressed in Hand2(-/-) vs wild-type mice. ...Nebulette was shown to be deleted in DiGeorge Syndrome 2 patients with the proximal deletion of human 10p13-p14 t …
We used differential display analysis to identify 33 putative HAND2-regulated ESTs that are differentially expressed in Hand2( …
The canonical Wnt signaling activator, R-spondin2, regulates craniofacial patterning and morphogenesis within the branchial arch through ectodermal-mesenchymal interaction.
Jin YR, Turcotte TJ, Crocker AL, Han XH, Yoon JK. Jin YR, et al. Dev Biol. 2011 Apr 1;352(1):1-13. doi: 10.1016/j.ydbio.2011.01.004. Epub 2011 Jan 13. Dev Biol. 2011. PMID: 21237142 Free PMC article.
R-spondins are a recently characterized family of secreted proteins that activate Wnt/beta-catenin signaling. Herein, we determine R-spondin2 (Rspo2) function in craniofacial development in mice. Mice lacking a functional Rspo2 gene exhibit craniofacial abnormali …
R-spondins are a recently characterized family of secreted proteins that activate Wnt/beta-catenin signaling. Herein, we determine R-spondin …
Specific inactivation of Twist1 in the mandibular arch neural crest cells affects the development of the ramus and reveals interactions with hand2.
Zhang Y, Blackwell EL, McKnight MT, Knutsen GR, Vu WT, Ruest LB. Zhang Y, et al. Dev Dyn. 2012 May;241(5):924-40. doi: 10.1002/dvdy.23776. Epub 2012 Mar 29. Dev Dyn. 2012. PMID: 22411303 Free PMC article.
RESULTS: The mutant mice exhibited a spectrum of craniofacial anomalies, including mandibular hypoplasia, altered middle ear development, and cleft palate. ...This gene is also needed to control the ossification of the mandible, a redundant role shared with Hand2. C …
RESULTS: The mutant mice exhibited a spectrum of craniofacial anomalies, including mandibular hypoplasia, altered middle ear developm …
30 results